September 19 - Andrew Pickens is born in Bucks County, Pennsylvania.
1761
- Andrew Pickens serves in Grant's Expedition against the Cherokee Indians.
1764
- Andrew Pickens and his brother sell their farm in the Waxhaws and move to the South Carolina Long Cane Creek settlements.
1765
- Andrew Pickens marries Rebecca Calhoun.
1768
- Andrew Pickens builds a blockhouse at the future location of Abbeville, South Carolina.
1775
- Andrew Pickens serves as a Patriot militia captain at Ninety-Six, South Carolina. November 21 - Andrew Pickens helps negotiate a truce with Tories at Ninety-Six, South Carolina
- Andrew Pickens serves in Snow's Campaign.
1776
- Andrew Pickens joins Williamson's Campaign against Cherokee.
1778
- Andrew Pickens joins Williamson's failed attempt to capture Augusta, Georgia.
1779 February 10 - Andrew Pickens besieges Fort Carr. February 14 - Andrew Pickens and Elijah Clarke defeat Tories at Kettle Creek, Georgia.
1780
- Andrew Pickens surrenders and goes home on parole.
- Andrew Pickens reenters the war after Tories raid his home.
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