Jed Bartlet (Martin Sheen): Democratic President of the United States from New Hampshire.
Abbey Bartlet (Stockard Channing): Fiesty First Lady with her own agenda focused on women's issues..
Charlie Young (Dule Hill): Young and fiercely loyal Personal Aide to the President.
C.J. Cregg (Allison Janney): White House Press Secretary.
Sam Seaborn (Rob Lowe): Idealistic Deputy Communications Director and speechwriter..
Will Bailey (Joshua Malina): Brilliant speechwriter who replaces Sam as Deputy Communications Director and then becomes Chief of Staff of Vice President Bob Russell.
Donna Moss (Janel Moloney): . Assistant to the Deputy Chief of Staff
Tobey Ziegler (Richard Schiff): White House Communications Director and speechwriter..
Leo McGarry (John Spencer): Chief of Staff of the President of the United States.
Josh Lyman (Bradley Whitford): Deputy Chief of Staff.